Sunday, 2 June 2013

New film puts UW breast-cancer researcher in spotlight | Movies ...

Originally published June 1, 2013 at 7:00 PM | Page modified June 1, 2013 at 7:58 PM

When Dr. Mary-Claire King, a geneticist at the University of Washington, learned Helen Hunt was portraying her in an upcoming feature film, she thought it must be a joke.

A graduate student in King?s lab stumbled across a description of the movie-in-progress on the Internet last winter. ?The student came to me and said, ?You didn?t tell me they were making a movie about you!??? King remembered in an interview last week. ?I said, ?Nobody?s making a movie about me.??? She thought the student, kidding around, had set up the Web page herself.

?Decoding Annie Parker? was indeed real. The film is based on two concurrent stories of real-life women: Anne Parker (played by Samantha Morton), a Toronto cancer survivor determined to understand why cancer repeatedly struck the women in her family, and King?s groundbreaking, decades-long work at the University of California, Berkeley, to discover the gene (BRCA1) that leads to increased risk of breast and ovarian cancer. The film screens this week at the Seattle International Film Festival as a benefit for King?s lab, currently developing accurate and affordable testing for BRCA1, BRCA2 and other genes that lead to breast or ovarian cancer.

Director Steven Bernstein, Parker, and King will all appear at the two screenings ? marking the first time the three have met, though all have corresponded, and Bernstein and Parker have appeared together at several previous charitable screenings of the film.

?Annie Parker is, I think, iconic of many women that I?ve met in the course of doing this work ? women who were stunned by what happened, devastated by what happened, and responded not by giving up but by learning, by becoming involved, by figuring out what had happened,? King said.

The subject matter of ?Decoding Annie Parker? is very much of the moment: Angelina Jolie?s announcement several weeks ago that she carried a mutation in the BRCA1 gene and underwent a preventive double mastectomy suddenly had everyone talking about inherited breast cancer.

King characterized Jolie?s editorial in The New York Times as ?a beautiful piece ... really good, very clear, very accurate,? but was careful to note that Jolie?s perspective, and Parker?s, are ?absolutely the correct perspective for each of them? but that everyone?s profile is different. Mutations in BRCA1 and BRCA2 can be inherited from fathers as well as from mothers, so many women who have the mutations in these genes have no family history of breast or ovarian cancer. And she notes that ?the vast, vast majority of women do not have mutations in either of these genes.?

Bernstein is currently seeking U.S. distribution for the film. A recent screening at Cannes garnered much interest but no deal yet. Bernstein is a longtime cinematographer who spent six years making ?Decoding Annie Parker,? his directorial debut. Years ago, he thought of a unique idea for its initial release: a ?little altruistic window? before the movie?s commercial debut, in which it would share screening revenues with charities. ?My investors stay happy, and I, rather than giving the money to a distributor right away, get to see that hopefully a few million dollars get to some cancer charities,? he said, noting that about 50 cities will host charitable screenings of the film.

After the film was completed earlier this year, Bernstein wrote to King and invited her to view the film. The filmmaker said he worried he might have done King ?a bit of a disservice? but believed he would write a better script if he did it ?once removed? ? without meeting King or Parker. Bernstein wrote the film, based on Parker?s story, with his son, Adam Bernstein, and physician Michael Moss, who advised on the story?s medical issues.

?The science is important, but I can?t tell you the science,? Bernstein said. ?What I can tell you ? this is what I have observed happens to people in the face of catastrophic illness, this is what happens to relationships ... That?s what I hoped to do with the film, and I thought I could only do that if I stepped away from the science.?

There are far fewer scenes of Hunt/King in the film than of Morton/Parker; the story focuses on Annie, and how her long fight against cancer changes her.

King acknowledged that as a scientist she had ?a few quibbles? with ?Decoding Annie Parker,? and one large concern: the film?s omission of Asian Americans in its depiction of her Berkeley lab. ?The idea that one could carry out serious science in America without the involvement of Asian Americans is just ludicrous,? she said. But she had high praise for Hunt, who?d clearly studied videos of King (?she?s got a bunch of mannerisms right!?), and found the film as a whole ?beautifully acted.?

?The story is gripping,? she said, ?and it will have enormous appeal to women who are concerned about breast cancer ? which is all of us.?

Moira Macdonald: 206-464-2725 or mmacdonald@seattletimes.com

Source: http://seattletimes.com/html/movies/2021104205_decodingannieparkerxml.html?syndication=rss

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How did the turtle get its shell?

A study of a 260-million-year-old fossil could help settle a debate about an evolutionary novelty.?

By Eoin O'Carroll,?Staff / May 31, 2013

A young African leopard tortoise, shown here in 1998.

Ari Denison / Christian Science Monitor

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How did the turtle get its shell?

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You'd be forgiven for thinking that Rudyard Kipling worked this out a century ago. It turns out that it's a tough one for biologists to crack.?

Many think that the turtle's shell developed from bony scales that fused with its ribcage, similar to what happened with armadillos and some lizards. Others think that the shell developed from the ribs themselves, which gradually grew broader and straighter until eventually forming an exterior shell.?

Scientists found little evidence either way. The oldest known turtle fossils, which are about 210 million years old, already had a fully formed shell, leaving paleontologists with few clues as to how it developed. ?

But now, an analysis of the fossilized remains of a creature that roamed what is now South Africa some 260 million years ago supports the second story.?

In a study published in the journal Current Biology, scientists at Yale University, the Smithsonian Institution, and the New York Institute of Technology examined 45 specimens of?Eunotosaurus, an extinct genus of primitive reptile. They found that many features of Eunotosaurus ? its distinctive T-shaped ribs, its elongated vertebrae ? mark it as an ancestor of the turtle.?

?Now we?ve got an intermediate shell, a transitional form that bridges the gap between turtles and other reptiles and helps explain how the turtle shell evolved,? said lead author?Tyler Lyson,?a curatorial affiliate of the Yale Peabody Museum of Natural History and a Smithsonian postdoctoral researcher, in a Yale press release.

The idea that Eunotosaurus is a turtle ancestor is not new. After it was discovered in the late 19th century, some scientists speculated that it belonged to the same order as modern day turtles. There was very little hard evidence for this claim, however, and support for it eventually vanished as more and more scientists became convinced that turtle shells developed armadillo-like, via external scales.

But then, five years ago, a 220-million-year-old fossil unearthed in China revealed the existence of a turtle-like reptile?with a fully developed underbelly shell and broad, flat ribs ? and no bony scales. This animal, called?Odontochelys semitestacea, showed that shells can form without scales. This discovery prompted researchers to revisit?Eunotosaurus.

?Our data supports Eunotosaurus as an important link in that evolutionary chain that eventually produced modern turtles,? said New York Institute of Technology anatomist study co-author Gaberiel Bever, in an NYIT press release.?"This is an earlier version of the turtle."

Not all scientists will be convinced by the team's evidence, however.?Eunotosaurus lacks some essential turtle features, such as a hard underbelly.?

"This is a highly contentious area," Dr. Lyson told the Los Angeles Times. "I'm sure I won't convince everybody, but I think it's a really good step forward."

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/30bic2N3arU/How-did-the-turtle-get-its-shell

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LightUp Helps Kids Learn Electronics With Augmented Reality

0a36ab7548760974096a9af1392e37e7_largeUnderstanding electronics is tricky. Electricity is invisible, the components are cryptic, and the concepts are hard to grasp. That's where LightUp comes in. This is an AR-based system for teaching electronics by allowing kids to build little projects and "see" what the components are doing using augmented reality.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/sD4ZhQszGSo/

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Saturday, 1 June 2013

Jailed Pussy Riot member ends hunger strike

MOSCOW (AP) ? A jailed member of the punk group Pussy Riot has ended her 11-day hunger strike Saturday after prison authorities met her demands, an activist said.

Maria Alekhina had complained that officials at her prison colony in the Ural Mountains attempted to turn fellow inmates against her with a security crackdown. Inmates, who could previously enter and leave their workplace freely, had to wait for up to an hour for prison guards to escort them.

Pyotr Verzilov, the husband of Alekhina's jailed band mate Nadezhda Tolokonnikova, told The Associated Press that Alekhina called Saturday to say she has ended her action after prison officials restored the normal security regime.

Verzilov said authorities took Alekhina, who was hospitalized Tuesday, on a tour across the prison colony, so that she sees that all extra security measures were removed. The extra security meant that inmates were denied prompt medical care when they sustained injuries during their work sewing uniforms.

"It looks improbable, it's not in the tradition of the prison system here to make any concessions," Verzilov said. "There must have been a political decision."

Alekhina's lawyer, Irina Khrunova, confirmed to the AP that she ended the hunger strike, but gave no further details.

Alekhina and Tolokonnikova are serving two-year sentences over an irreverent punk protest against Vladimir Putin in Moscow's main cathedral. The third band member convicted alongside them, Yekaterina Samutsevich, was later released on appeal.

Courts have denied parole to Alekhina and Tolokonnikova, who are serving their sentence in different prison colonies.

Alekhina earlier spent five months in solitary confinement after claiming that officials deliberately lodged her with hardened criminals, including a convicted murderer, and encouraged them to intimidate her.

In a complaint filed in January, Khrunova wrote that officials did nothing after seeing criminals threaten Alekhina with violence. The lawyer said officials also wrote false psychiatric reports and pushed Alekhina into violating colony rules.

Source: http://news.yahoo.com/jailed-pussy-riot-member-ends-hunger-strike-132808247.html

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This Longboard Stroller Might Help You Fend Off Parental Lameness

Once you have kids your coolness factor starts a slow but inevitable decline towards a lame life of tucking in Polo shirts and constantly stressing over mutual funds. But before your kids reach their teenage years, there are ways to prolong your coolness, like swapping your stroller?as expensive or tricked out as it may be?with one that's attached to a longboard.

Assuming you're an experienced skater who hasn't fallen in years, these Longboard Strollers provide a more entertaining option for carting your kids around since you get to come along for the ride. There's no word on pricing or availability just yet, or how much paper work you'll need to fill out so its creators aren't held legally responsible when you inevitably crash, but the Longboard Strollers have reached the prototype stage without any serious reported injuries?with the emphasis on reported. [Longboard Stroller via Gizmag]

Source: http://gizmodo.com/this-longboard-stroller-might-help-you-fend-off-parenta-510721033

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Gay rights cases could trail Obama in Africa

WASHINGTON (AP) ? President Barack Obama's trip to Africa next month may result in a stark juxtaposition between the growing power of the gay rights movement in the U.S. and the criminalization of homosexuality throughout the African continent.

Obama is scheduled to be in Africa in late June and early July ? the same period in which the Supreme Court is likely to issue highly anticipated rulings on a pair of gay marriage cases. The court does not say in advance when its rulings will be issued, but the gay marriage cases are expected to be among the last decisions announced before the justices begin their summer break at the end of June.

Homosexuality is considered a criminal offense in many African nations, including Senegal and Tanzania, two of the countries Obama will visit. South Africa, the third country on the president's itinerary, has broad protections for homosexuals and is the only African country to legalize gay marriage.

Gay rights activist Richard Socarides said Obama could use the rulings as a "teachable moment" if the justices move to expand rights for same-sex couples.

"If the timing works out so that he's there, it may provide a perfect opportunity for him to speak out about the principles we value in our democracy and how we would hope that others follow it," said Socarides, who worked in the White House during the Clinton administration.

The White House wouldn't say what role gay rights would play in Obama's trip but noted that the administration "unequivocally advocates against violence and discrimination" against gays and lesbians, both in Africa and elsewhere around the world.

One of the cases before the Supreme Court is a challenge to California's voter-approved Proposition 8 that defines marriage as the union of a man and a woman. The other seeks to strike down a portion of the federal Defense of Marriage Act that denies to legally married same-sex couples a range of benefits that generally are available to married heterosexuals. Obama supports overturning both measures.

The president has frequently called on countries around the world to end discrimination against gays and lesbians. In 2011, he directed the State Department to "ensure that U.S. diplomacy and foreign assistance promote and protect the human rights of" gays, lesbians and transgender people. That included having diplomats "combat the criminalization" of being gay by foreign governments.

According to the State Department's 2012 human rights report on Tanzania, consensual same-sex sexual conduct is illegal and carries a prison sentence of 30 years to life. The report also concluded that gays and lesbians face "societal discrimination that restricted their access to health care, housing and employment" and that there were no government efforts to combat such discrimination.

Conditions are similar in Senegal, according to the State Department. The agency's 2012 human rights report on the West African nation says consensual same-sex activity, referred to in the law as an "act against nature," is a criminal offense.

Underscoring the continent's tough penalties for gays and lesbians, Nigeria's House of Representatives voted Thursday to ban gay marriage and outlaw any groups actively supporting gay rights, endorsing a measure that also calls for 10-year prison sentences for any public show of affection by a same-sex couple. It's unclear whether Nigeria's president will sign the measure.

___

Associated Press writer Mark Sherman contributed to this report.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-05-31-US-Obama-Africa-Gay-Rights/id-aeffa8a4b0ad44e3800a6abdd4b1385e

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A Better Predictor of Autism

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